Drug interactions
Atenolol-chlorthalidone + Tolfenamic acid
Severity: Moderate
Atenolol-chlorthalidone and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid can weaken the antihypertensive effect of atenolol and chlorthalidone through prostaglandin inhibition and fluid retention. With diuretics they also increase the risk of reduced renal function.
What this interaction means in plain words
Atenolol-chlorthalidone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis causing sodium and water retention and reduced renal perfusion.
What to do
Monitor blood pressure and renal function if used for more than a few days. Use the lowest effective dose for the shortest duration, or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Atenolol-chlorthalidone with Tolfenamic acid?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid can weaken the antihypertensive effect of atenolol and chlorthalidone through prostaglandin inhibition and fluid retention. With diuretics they also increase the risk of reduced renal function.
How serious is the interaction between Atenolol-chlorthalidone and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if used for more than a few days. Use the lowest effective dose for the shortest duration, or choose an alternative analgesic.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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