Drug interactions
Atenolol-chlorthalidone + Treprostinil
Severity: Moderate
Atenolol-chlorthalidone and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator and may add to the blood pressure-lowering effects of atenolol and chlorthalidone. Symptomatic hypotension can occur, especially when starting or increasing the dose.
What this interaction means in plain words
Atenolol-chlorthalidone and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atenolol-chlorthalidone belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects.
What to do
Monitor blood pressure when initiating or titrating treprostinil and reduce antihypertensive doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Treprostinil
Frequently asked questions
Can I take Atenolol-chlorthalidone with Treprostinil?
MediHelp rates the interaction as moderate. Atenolol-chlorthalidone and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator and may add to the blood pressure-lowering effects of atenolol and chlorthalidone. Symptomatic hypotension can occur, especially when starting or increasing the dose.
How serious is the interaction between Atenolol-chlorthalidone and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when initiating or titrating treprostinil and reduce antihypertensive doses if hypotension occurs.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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