Drug interactions
Atidarsagene autotemcel + Hepatitis A vaccine inactivated
Severity: Moderate
Atidarsagene autotemcel and Hepatitis A vaccine inactivated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atidarsagene autotemcel is a gene therapy given after myeloablative conditioning, leaving patients with a temporarily absent or recovering immune system. Vaccines given around this period may be ineffective, and their safety has not been studied.
What this interaction means in plain words
Atidarsagene autotemcel and Hepatitis A vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atidarsagene autotemcel belongs to Miscellaneous; Hepatitis A vaccine inactivated belongs to Anti Virals.
Why it happens
Pharmacodynamic: myeloablative conditioning and hematologic reconstitution impair the immune response to vaccination.
What to do
Give vaccines, where feasible, before myeloablative conditioning and avoid vaccination in the 6 weeks before conditioning. Postpone further vaccination until hematologic recovery, then revaccinate as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Other interactions of Atidarsagene autotemcel
Frequently asked questions
Can I take Atidarsagene autotemcel with Hepatitis A vaccine inactivated?
MediHelp rates the interaction as moderate. Atidarsagene autotemcel and Hepatitis A vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atidarsagene autotemcel is a gene therapy given after myeloablative conditioning, leaving patients with a temporarily absent or recovering immune system. Vaccines given around this period may be ineffective, and their safety has not been studied.
How serious is the interaction between Atidarsagene autotemcel and Hepatitis A vaccine inactivated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give vaccines, where feasible, before myeloablative conditioning and avoid vaccination in the 6 weeks before conditioning. Postpone further vaccination until hematologic recovery, then revaccinate as needed.
What other medicines interact with Hepatitis A vaccine inactivated?
MediHelp also lists interactions of Hepatitis A vaccine inactivated with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Hepatitis A vaccine inactivated page.
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