Drug interactions
Atidarsagene autotemcel + Measles mumps and rubella vaccine
Severity: Major
Atidarsagene autotemcel and Measles mumps and rubella vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atidarsagene autotemcel requires myeloablative conditioning, leaving patients immunosuppressed until hematologic recovery. Live MMR vaccine in this period could cause disseminated vaccine-strain infection and would be ineffective.
What this interaction means in plain words
Atidarsagene autotemcel and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Measles mumps and rubella vaccine belongs to Miscellaneous.
Why it happens
Myeloablative conditioning and hematopoietic reconstitution cause profound immunosuppression, allowing replication of live attenuated virus.
What to do
Give MMR at least 6 weeks before conditioning where feasible; defer live vaccines until hematologic and immune recovery is confirmed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Atidarsagene autotemcel
Frequently asked questions
Can I take Atidarsagene autotemcel with Measles mumps and rubella vaccine?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atidarsagene autotemcel requires myeloablative conditioning, leaving patients immunosuppressed until hematologic recovery. Live MMR vaccine in this period could cause disseminated vaccine-strain infection and would be ineffective.
How serious is the interaction between Atidarsagene autotemcel and Measles mumps and rubella vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give MMR at least 6 weeks before conditioning where feasible; defer live vaccines until hematologic and immune recovery is confirmed.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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