Drug interactions
Atidarsagene autotemcel + Dolutegravir
Severity: Major
Atidarsagene autotemcel and Dolutegravir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antiretroviral drugs can interfere with manufacture of this lentiviral gene therapy by inhibiting transduction. Dolutegravir, an integrase inhibitor, may compromise product quality if present at apheresis.
What this interaction means in plain words
Atidarsagene autotemcel and Dolutegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Dolutegravir belongs to Anti Virals.
Why it happens
Antiretroviral activity inhibits lentiviral vector transduction of harvested cells.
What to do
Stop dolutegravir at least one month before mobilization, allowing for elimination, and keep it off through apheresis. Arrange interim HIV management with specialists.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dolutegravir
Other interactions of Atidarsagene autotemcel
Frequently asked questions
Can I take Atidarsagene autotemcel with Dolutegravir?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Dolutegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretroviral drugs can interfere with manufacture of this lentiviral gene therapy by inhibiting transduction. Dolutegravir, an integrase inhibitor, may compromise product quality if present at apheresis.
How serious is the interaction between Atidarsagene autotemcel and Dolutegravir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop dolutegravir at least one month before mobilization, allowing for elimination, and keep it off through apheresis. Arrange interim HIV management with specialists.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Betibeglogene autotemcel. The full list is on the Dolutegravir page.
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