Drug interactions
Atomoxetine + Doxepin
Severity: Moderate
Atomoxetine and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a tricyclic antidepressant that is metabolized in part by CYP2D6, which atomoxetine does not meaningfully inhibit, but both agents can affect cardiac conduction and heart rate. Combined use may increase the risk of QT prolongation and tachycardia.
What this interaction means in plain words
Atomoxetine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Doxepin belongs to Dermatology.
Why it happens
Additive QT prolongation and noradrenergic cardiovascular effects.
What to do
Monitor ECG and heart rate, particularly at higher doxepin doses or with cardiac risk factors. Correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Atomoxetine with Doxepin?
MediHelp rates the interaction as moderate. Atomoxetine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a tricyclic antidepressant that is metabolized in part by CYP2D6, which atomoxetine does not meaningfully inhibit, but both agents can affect cardiac conduction and heart rate. Combined use may increase the risk of QT prolongation and tachycardia.
How serious is the interaction between Atomoxetine and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, particularly at higher doxepin doses or with cardiac risk factors. Correct electrolyte abnormalities.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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