Drug interactions
Doxepin + Tranylcypromine
Severity: Contraindicated
Doxepin and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin inhibits serotonin and norepinephrine reuptake, and combining a tricyclic with an MAOI can cause serotonin syndrome or hypertensive crisis. Some specialist regimens use cautious combinations, but routine use is hazardous.
What this interaction means in plain words
Doxepin and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Doxepin belongs to Dermatology; Tranylcypromine belongs to Central Nervous System.
Why it happens
Reuptake inhibition plus irreversible MAO inhibition increases synaptic serotonin and norepinephrine.
What to do
Avoid the combination. Allow a washout of at least 14 days after stopping tranylcypromine before starting doxepin, and a suitable washout in the other direction.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Amisulpride + Doxepin Major
Frequently asked questions
Can I take Doxepin with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Doxepin and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Doxepin inhibits serotonin and norepinephrine reuptake, and combining a tricyclic with an MAOI can cause serotonin syndrome or hypertensive crisis. Some specialist regimens use cautious combinations, but routine use is hazardous.
How serious is the interaction between Doxepin and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Allow a washout of at least 14 days after stopping tranylcypromine before starting doxepin, and a suitable washout in the other direction.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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