Drug interactions
Doxepin + Procarbazine
Severity: Contraindicated
Doxepin and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO inhibitor activity, and doxepin is a tricyclic antidepressant that blocks serotonin and noradrenaline reuptake. The pair can cause serotonin syndrome or hypertensive episodes, with agitation, fever, tremor, and autonomic instability.
What this interaction means in plain words
Doxepin and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Doxepin belongs to Dermatology; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition plus monoamine reuptake blockade raises synaptic serotonin and noradrenaline.
What to do
Avoid the combination. Allow a washout of at least 14 days between stopping procarbazine and starting doxepin, and the reverse.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
- Amisulpride + Doxepin Major
Frequently asked questions
Can I take Doxepin with Procarbazine?
MediHelp rates the interaction as contraindicated. Doxepin and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO inhibitor activity, and doxepin is a tricyclic antidepressant that blocks serotonin and noradrenaline reuptake. The pair can cause serotonin syndrome or hypertensive episodes, with agitation, fever, tremor, and autonomic instability.
How serious is the interaction between Doxepin and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Allow a washout of at least 14 days between stopping procarbazine and starting doxepin, and the reverse.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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