Drug interactions
Atomoxetine + Flecainide
Severity: Moderate
Atomoxetine and Flecainide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atomoxetine has been associated with QT prolongation, particularly at high exposures, and flecainide has proarrhythmic potential. Together they may increase the chance of serious ventricular arrhythmias. Atomoxetine can also raise heart rate and blood pressure, which may be unfavorable in patients with arrhythmia.
What this interaction means in plain words
Atomoxetine and Flecainide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Flecainide belongs to Cardiovascular.
Why it happens
Additive effects on cardiac repolarization and conduction; atomoxetine is a CYP2D6 substrate and a weak inhibitor, with the interaction not well characterized.
What to do
Use an alternative ADHD treatment if feasible; otherwise monitor ECG and heart rate and blood pressure when starting or adjusting either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atomoxetine and Flecainide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Flecainide?
MediHelp rates the interaction as moderate. Atomoxetine and Flecainide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atomoxetine has been associated with QT prolongation, particularly at high exposures, and flecainide has proarrhythmic potential. Together they may increase the chance of serious ventricular arrhythmias. Atomoxetine can also raise heart rate and blood pressure, which may be unfavorable in patients with arrhythmia.
How serious is the interaction between Atomoxetine and Flecainide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative ADHD treatment if feasible; otherwise monitor ECG and heart rate and blood pressure when starting or adjusting either drug.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
