Drug interactions
Atomoxetine + Histrelin
Severity: Moderate
Atomoxetine and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, may prolong the QT interval through androgen deprivation, and atomoxetine may add to this. The clinical significance is likely modest but relevant in patients with other arrhythmia risk factors.
What this interaction means in plain words
Atomoxetine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Histrelin belongs to Musculoskeletal.
Why it happens
Possible additive QTc prolongation; androgen deprivation therapy is associated with QT lengthening.
What to do
Consider baseline and periodic ECG monitoring and keep potassium and magnesium within normal range. Avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atomoxetine and Histrelin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Atomoxetine with Histrelin?
MediHelp rates the interaction as moderate. Atomoxetine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, may prolong the QT interval through androgen deprivation, and atomoxetine may add to this. The clinical significance is likely modest but relevant in patients with other arrhythmia risk factors.
How serious is the interaction between Atomoxetine and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline and periodic ECG monitoring and keep potassium and magnesium within normal range. Avoid adding further QT-prolonging drugs.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
