Drug interactions
Amisulpride + Histrelin
Severity: Moderate
Amisulpride and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with GnRH agonists such as histrelin can prolong the QT interval. Added to amisulpride, this may increase arrhythmia risk, although the effect of histrelin is modest.
What this interaction means in plain words
Amisulpride and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation; GnRH agonist effect is thought to arise from androgen suppression.
What to do
Obtain a baseline ECG and monitor periodically, particularly with other risk factors. Correct potassium and magnesium disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Asenapine + Histrelin Moderate
- Atomoxetine + Histrelin Moderate
Frequently asked questions
Can I take Amisulpride with Histrelin?
MediHelp rates the interaction as moderate. Amisulpride and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with GnRH agonists such as histrelin can prolong the QT interval. Added to amisulpride, this may increase arrhythmia risk, although the effect of histrelin is modest.
How serious is the interaction between Amisulpride and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor periodically, particularly with other risk factors. Correct potassium and magnesium disturbances.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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