Drug interactions
Asenapine + Histrelin
Severity: Moderate
Asenapine and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin is a GnRH agonist, and androgen deprivation therapy can prolong the QT interval. Asenapine adds a separate QT effect, so the combination may modestly raise arrhythmia risk.
What this interaction means in plain words
Asenapine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation; the GnRH agonist effect arises from hormonal suppression and is less direct than channel blockade.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities before combining. Periodically monitor QTc, especially in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Atomoxetine + Histrelin Moderate
Frequently asked questions
Can I take Asenapine with Histrelin?
MediHelp rates the interaction as moderate. Asenapine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin is a GnRH agonist, and androgen deprivation therapy can prolong the QT interval. Asenapine adds a separate QT effect, so the combination may modestly raise arrhythmia risk.
How serious is the interaction between Asenapine and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities before combining. Periodically monitor QTc, especially in patients with other risk factors.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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