Drug interactions
Atomoxetine + Lapatinib
Severity: Moderate
Atomoxetine and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can prolong the QT interval, and atomoxetine has been linked to QT effects mainly in overdose or in poor CYP2D6 metabolizers. Combined use may add to arrhythmia risk, particularly in patients with other risk factors.
What this interaction means in plain words
Atomoxetine and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and monitor it during therapy, and keep potassium and magnesium within normal range. Avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Atomoxetine with Lapatinib?
MediHelp rates the interaction as moderate. Atomoxetine and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib can prolong the QT interval, and atomoxetine has been linked to QT effects mainly in overdose or in poor CYP2D6 metabolizers. Combined use may add to arrhythmia risk, particularly in patients with other risk factors.
How serious is the interaction between Atomoxetine and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during therapy, and keep potassium and magnesium within normal range. Avoid other QT-prolonging drugs where possible.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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