Drug interactions
Atomoxetine + Memantine-donepezil
Severity: Moderate
Atomoxetine and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil is associated with QT prolongation and torsades de pointes, and atomoxetine may modestly affect QT, especially at high exposure. The combination may increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Atomoxetine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization (QT prolongation).
What to do
Check ECG and electrolytes in patients with cardiac disease, bradycardia or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Memantine-donepezil?
MediHelp rates the interaction as moderate. Atomoxetine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil is associated with QT prolongation and torsades de pointes, and atomoxetine may modestly affect QT, especially at high exposure. The combination may increase arrhythmia risk in susceptible patients.
How serious is the interaction between Atomoxetine and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with cardiac disease, bradycardia or other QT-prolonging drugs.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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