Drug interactions
Atomoxetine + Mifepristone
Severity: Major
Atomoxetine and Mifepristone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, particularly at the higher doses used for Cushing syndrome, prolongs the QT interval. Atomoxetine may add to this, and mifepristone also inhibits CYP2D6, which can raise atomoxetine exposure.
What this interaction means in plain words
Atomoxetine and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atomoxetine belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Additive QT prolongation, with mifepristone-mediated CYP2D6 inhibition increasing atomoxetine levels.
What to do
Avoid combining where possible when mifepristone is used at Cushing-syndrome doses. If necessary, obtain ECG monitoring, correct potassium, and consider reducing the atomoxetine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Atomoxetine with Mifepristone?
MediHelp rates the interaction as major. Atomoxetine and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone, particularly at the higher doses used for Cushing syndrome, prolongs the QT interval. Atomoxetine may add to this, and mifepristone also inhibits CYP2D6, which can raise atomoxetine exposure.
How serious is the interaction between Atomoxetine and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible when mifepristone is used at Cushing-syndrome doses. If necessary, obtain ECG monitoring, correct potassium, and consider reducing the atomoxetine dose.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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