Drug interactions
Atomoxetine + Sertraline
Severity: Moderate
Atomoxetine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atomoxetine is metabolized by CYP2D6, and sertraline is a mild to moderate inhibitor at higher doses, which may raise atomoxetine levels. Increased heart rate, blood pressure and other adverse effects may result.
What this interaction means in plain words
Atomoxetine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by sertraline reduces atomoxetine clearance, with possible additive QT effect.
What to do
Monitor heart rate, blood pressure and adverse effects, and consider a lower atomoxetine dose if sertraline is used at higher doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atomoxetine and Sertraline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Sertraline?
MediHelp rates the interaction as moderate. Atomoxetine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atomoxetine is metabolized by CYP2D6, and sertraline is a mild to moderate inhibitor at higher doses, which may raise atomoxetine levels. Increased heart rate, blood pressure and other adverse effects may result.
How serious is the interaction between Atomoxetine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and adverse effects, and consider a lower atomoxetine dose if sertraline is used at higher doses.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
