Drug interactions
Atomoxetine + Tetrabenazine
Severity: Moderate
Atomoxetine and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine causes dose-related QT prolongation, and atomoxetine may contribute a small additional effect. Tetrabenazine is metabolized by CYP2D6, so exposure to its active metabolites may also be higher in poor metabolizers.
What this interaction means in plain words
Atomoxetine and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with both drugs depending on CYP2D6 metabolism.
What to do
Obtain a baseline ECG and monitor QTc, especially during tetrabenazine dose increases. Avoid the combination in patients with congenital long QT or other significant QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Atomoxetine with Tetrabenazine?
MediHelp rates the interaction as moderate. Atomoxetine and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetrabenazine causes dose-related QT prolongation, and atomoxetine may contribute a small additional effect. Tetrabenazine is metabolized by CYP2D6, so exposure to its active metabolites may also be higher in poor metabolizers.
How serious is the interaction between Atomoxetine and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, especially during tetrabenazine dose increases. Avoid the combination in patients with congenital long QT or other significant QT risk factors.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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