Drug interactions
Linezolid + Tetrabenazine
Severity: Contraindicated
Linezolid and Tetrabenazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine releases/depletes monoamine stores and MAO inhibitors are contraindicated with it because of the risk of hypertensive reactions. Linezolid, with MAO-inhibiting activity, may therefore provoke acute hypertension.
What this interaction means in plain words
Linezolid and Tetrabenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Linezolid belongs to Anti Bacterial; Tetrabenazine belongs to Central Nervous System.
Why it happens
MAO inhibition by linezolid allows norepinephrine accumulation in neurons, and tetrabenazine-induced release produces an exaggerated pressor response.
What to do
Avoid the combination and separate an MAOI from tetrabenazine by about 14 days where feasible. Use a non-MAOI antibiotic instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
- Rasagiline + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Linezolid with Tetrabenazine?
MediHelp rates the interaction as contraindicated. Linezolid and Tetrabenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tetrabenazine releases/depletes monoamine stores and MAO inhibitors are contraindicated with it because of the risk of hypertensive reactions. Linezolid, with MAO-inhibiting activity, may therefore provoke acute hypertension.
How serious is the interaction between Linezolid and Tetrabenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and separate an MAOI from tetrabenazine by about 14 days where feasible. Use a non-MAOI antibiotic instead.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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