Drug interactions
Procarbazine + Tetrabenazine
Severity: Contraindicated
Procarbazine and Tetrabenazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine releases and depletes monoamines, and with an MAO inhibitor such as procarbazine this can cause a hypertensive episode. Tetrabenazine labeling contraindicates use with MAOIs.
What this interaction means in plain words
Procarbazine and Tetrabenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Procarbazine belongs to Oncology; Tetrabenazine belongs to Central Nervous System.
Why it happens
MAO inhibition lets norepinephrine accumulate in neurons while tetrabenazine alters its release, causing pressor excess.
What to do
Do not combine; allow at least 14 days between stopping an MAOI and starting tetrabenazine. Select a different therapy for chorea if procarbazine is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Rasagiline + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Tetrabenazine?
MediHelp rates the interaction as contraindicated. Procarbazine and Tetrabenazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tetrabenazine releases and depletes monoamines, and with an MAO inhibitor such as procarbazine this can cause a hypertensive episode. Tetrabenazine labeling contraindicates use with MAOIs.
How serious is the interaction between Procarbazine and Tetrabenazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days between stopping an MAOI and starting tetrabenazine. Select a different therapy for chorea if procarbazine is needed.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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