Drug interactions
Atomoxetine + Vardenafil
Severity: Moderate
Atomoxetine and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, though atomoxetine's effect is generally small at therapeutic doses. Risk is higher with CYP2D6 poor metabolism, electrolyte disturbance or heart disease.
What this interaction means in plain words
Atomoxetine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Potential additive QT interval prolongation.
What to do
Avoid in patients with congenital long QT or uncorrected hypokalemia/hypomagnesemia; consider baseline ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Vardenafil?
MediHelp rates the interaction as moderate. Atomoxetine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, though atomoxetine's effect is generally small at therapeutic doses. Risk is higher with CYP2D6 poor metabolism, electrolyte disturbance or heart disease.
How serious is the interaction between Atomoxetine and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with congenital long QT or uncorrected hypokalemia/hypomagnesemia; consider baseline ECG in patients with cardiac risk factors.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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