Drug interactions
Atorvastatin + Erdafitinib
Severity: Moderate
Atorvastatin and Erdafitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib may inhibit intestinal P-glycoprotein and raise atorvastatin exposure. Higher statin levels can increase the risk of muscle toxicity, although the effect is probably modest.
What this interaction means in plain words
Atorvastatin and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Erdafitinib belongs to Oncology.
Why it happens
Erdafitinib inhibits P-glycoprotein efflux, which may increase absorption and systemic exposure of atorvastatin.
What to do
Monitor for myalgia, weakness and CK elevation, and use the lowest effective atorvastatin dose. Separating doses by about 6 hours is recommended in labeling for P-gp substrates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Atorvastatin with Erdafitinib?
MediHelp rates the interaction as moderate. Atorvastatin and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib may inhibit intestinal P-glycoprotein and raise atorvastatin exposure. Higher statin levels can increase the risk of muscle toxicity, although the effect is probably modest.
How serious is the interaction between Atorvastatin and Erdafitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia, weakness and CK elevation, and use the lowest effective atorvastatin dose. Separating doses by about 6 hours is recommended in labeling for P-gp substrates.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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