Drug interactions
Atorvastatin + Glyburide-metformin
Severity: Minor
Atorvastatin and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide may inhibit OATP1B1-mediated hepatic uptake of atorvastatin, raising its plasma levels slightly. The theoretical consequence is a higher risk of statin-related myopathy, although the clinical impact is generally small.
What this interaction means in plain words
Atorvastatin and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Inhibition of OATP1B1 hepatic uptake transport reduces atorvastatin clearance.
What to do
No dose adjustment is usually required; advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Glyburide-metformin?
MediHelp rates the interaction as minor. Atorvastatin and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glyburide may inhibit OATP1B1-mediated hepatic uptake of atorvastatin, raising its plasma levels slightly. The theoretical consequence is a higher risk of statin-related myopathy, although the clinical impact is generally small.
How serious is the interaction between Atorvastatin and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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