Drug interactions
Atorvastatin + Larotrectinib
Severity: Minor
Atorvastatin and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with only weak inhibitory potential in vitro. Any rise in atorvastatin exposure is expected to be modest.
What this interaction means in plain words
Atorvastatin and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Larotrectinib belongs to Oncology.
Why it happens
Possible weak inhibition of CYP3A4-mediated atorvastatin metabolism.
What to do
No empirical dose change is needed; counsel the patient to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Atorvastatin with Larotrectinib?
MediHelp rates the interaction as minor. Atorvastatin and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with only weak inhibitory potential in vitro. Any rise in atorvastatin exposure is expected to be modest.
How serious is the interaction between Atorvastatin and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; counsel the patient to report unexplained muscle pain or weakness.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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