Drug interactions
Atorvastatin + Metformin-repaglinide
Severity: Minor
Atorvastatin and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide inhibits OATP1B1 and may raise atorvastatin exposure, which could increase the risk of statin-related muscle toxicity. The effect is likely small at usual doses.
What this interaction means in plain words
Atorvastatin and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
Repaglinide inhibits OATP1B1-mediated hepatic uptake of atorvastatin.
What to do
No routine change is needed; advise patients to report unexplained muscle pain or weakness and check CK if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Metformin-repaglinide?
MediHelp rates the interaction as minor. Atorvastatin and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repaglinide inhibits OATP1B1 and may raise atorvastatin exposure, which could increase the risk of statin-related muscle toxicity. The effect is likely small at usual doses.
How serious is the interaction between Atorvastatin and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; advise patients to report unexplained muscle pain or weakness and check CK if symptoms occur.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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