Drug interactions
Atorvastatin + Nilotinib
Severity: Moderate
Atorvastatin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may raise atorvastatin concentrations, increasing the risk of statin-related myopathy. Nilotinib also prolongs the QT interval and its own exposure may be affected by other CYP3A4 or P-glycoprotein interactions.
What this interaction means in plain words
Atorvastatin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4 (and possibly P-glycoprotein), reducing atorvastatin clearance.
What to do
Use the lowest effective atorvastatin dose and monitor for muscle pain, weakness or dark urine, checking CK if symptoms appear. Consider a statin less dependent on CYP3A4 if problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Atorvastatin with Nilotinib?
MediHelp rates the interaction as moderate. Atorvastatin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may raise atorvastatin concentrations, increasing the risk of statin-related myopathy. Nilotinib also prolongs the QT interval and its own exposure may be affected by other CYP3A4 or P-glycoprotein interactions.
How serious is the interaction between Atorvastatin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective atorvastatin dose and monitor for muscle pain, weakness or dark urine, checking CK if symptoms appear. Consider a statin less dependent on CYP3A4 if problems arise.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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