Drug interactions
Atorvastatin + Primidone
Severity: Moderate
Atorvastatin and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital, which induces CYP3A4 and may reduce atorvastatin concentrations. This could lead to reduced lipid lowering.
What this interaction means in plain words
Atorvastatin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Primidone belongs to Central Nervous System.
Why it happens
Primidone and its phenobarbital metabolite induce CYP3A4, increasing atorvastatin metabolism.
What to do
Monitor the lipid profile and adjust the atorvastatin dose as needed. Reassess if primidone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Atorvastatin with Primidone?
MediHelp rates the interaction as moderate. Atorvastatin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital, which induces CYP3A4 and may reduce atorvastatin concentrations. This could lead to reduced lipid lowering.
How serious is the interaction between Atorvastatin and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid profile and adjust the atorvastatin dose as needed. Reassess if primidone is stopped.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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