Drug interactions
Atorvastatin + Sacubitril-valsartan
Severity: Minor
Atorvastatin and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril/valsartan modestly raises atorvastatin exposure, probably via OATP1B1 inhibition, while statins may also affect valsartan uptake. The changes are small, and an increased risk of muscle toxicity is uncertain.
What this interaction means in plain words
Atorvastatin and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Inhibition of the hepatic uptake transporters OATP1B1 and OATP1B3 by sacubitril or its metabolite.
What to do
No dose change is routinely needed. Ask patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Atorvastatin and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sacubitril/valsartan modestly raises atorvastatin exposure, probably via OATP1B1 inhibition, while statins may also affect valsartan uptake. The changes are small, and an increased risk of muscle toxicity is uncertain.
How serious is the interaction between Atorvastatin and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Ask patients to report unexplained muscle pain or weakness.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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