Drug interactions
Atorvastatin + Sotorasib
Severity: Moderate
Atorvastatin and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib can alter the exposure of drugs that are substrates of P-glycoprotein and CYP3A4. Atorvastatin is a substrate of both, so its exposure may change, but the clinical significance is not well characterised.
What this interaction means in plain words
Atorvastatin and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Sotorasib belongs to Oncology.
Why it happens
Sotorasib is a weak CYP3A4 inducer and P-gp inhibitor, so it may modify atorvastatin absorption and metabolism.
What to do
Monitor lipid response and for muscle symptoms during co-therapy. Adjust the atorvastatin dose if the lipid response is lost or muscle toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Atorvastatin with Sotorasib?
MediHelp rates the interaction as moderate. Atorvastatin and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib can alter the exposure of drugs that are substrates of P-glycoprotein and CYP3A4. Atorvastatin is a substrate of both, so its exposure may change, but the clinical significance is not well characterised.
How serious is the interaction between Atorvastatin and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid response and for muscle symptoms during co-therapy. Adjust the atorvastatin dose if the lipid response is lost or muscle toxicity occurs.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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