Drug interactions
Atorvastatin + Topotecan
Severity: Minor
Atorvastatin and Topotecan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin is a weak P-gp inhibitor and its effect on topotecan exposure is probably small. Oral topotecan labeling cautions against P-gp inhibitors, so a modest increase in topotecan toxicity such as myelosuppression is possible.
What this interaction means in plain words
Atorvastatin and Topotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Topotecan belongs to Oncology.
Why it happens
Possible weak inhibition of intestinal P-glycoprotein/BCRP efflux of topotecan.
What to do
Monitor blood counts as usual during topotecan therapy, particularly with oral topotecan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporin + Topotecan Major
- Darunavir + Topotecan Major
Frequently asked questions
Can I take Atorvastatin with Topotecan?
MediHelp rates the interaction as minor. Atorvastatin and Topotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atorvastatin is a weak P-gp inhibitor and its effect on topotecan exposure is probably small. Oral topotecan labeling cautions against P-gp inhibitors, so a modest increase in topotecan toxicity such as myelosuppression is possible.
How serious is the interaction between Atorvastatin and Topotecan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts as usual during topotecan therapy, particularly with oral topotecan.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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