Drug interactions
Atorvastatin + Vincristine
Severity: Minor
Atorvastatin and Vincristine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is a P-glycoprotein and CYP3A substrate, and atorvastatin is only a weak P-glycoprotein inhibitor. A clinically relevant increase in vincristine neurotoxicity is not well documented.
What this interaction means in plain words
Atorvastatin and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Vincristine belongs to Oncology.
Why it happens
Possible weak P-glycoprotein inhibition by atorvastatin.
What to do
No dose change is needed. Monitor for peripheral neuropathy and constipation as part of standard vincristine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Atorvastatin with Vincristine?
MediHelp rates the interaction as minor. Atorvastatin and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vincristine is a P-glycoprotein and CYP3A substrate, and atorvastatin is only a weak P-glycoprotein inhibitor. A clinically relevant increase in vincristine neurotoxicity is not well documented.
How serious is the interaction between Atorvastatin and Vincristine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for peripheral neuropathy and constipation as part of standard vincristine care.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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