Drug interactions
Atovaquone + Indinavir
Severity: Minor
Atovaquone and Indinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir has been reported to have little effect on indinavir levels but may modestly lower atovaquone exposure. The significance is uncertain and is likely small.
What this interaction means in plain words
Atovaquone and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
The mechanism is not established.
What to do
No empiric change is needed; monitor for response to atovaquone, especially when used for treatment of active infection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atovaquone
- Atovaquone + Rifampin Major
- Atovaquone + Efavirenz Moderate
- Atovaquone + Metoclopramide Moderate
- Atovaquone + Rifabutin Moderate
- Atovaquone + Warfarin Moderate
- Atovaquone + Metoclopramide intranasal Minor
Frequently asked questions
Can I take Atovaquone with Indinavir?
MediHelp rates the interaction as minor. Atovaquone and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir has been reported to have little effect on indinavir levels but may modestly lower atovaquone exposure. The significance is uncertain and is likely small.
How serious is the interaction between Atovaquone and Indinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric change is needed; monitor for response to atovaquone, especially when used for treatment of active infection.
What other medicines interact with Atovaquone?
MediHelp also lists interactions of Atovaquone with, for example, Rifampin, Efavirenz, Metoclopramide. The full list is on the Atovaquone page.
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