Drug interactions
Atovaquone + Metoclopramide intranasal
Severity: Minor
Atovaquone and Metoclopramide intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral metoclopramide has been reported to lower atovaquone plasma concentrations, possibly through its effect on gastrointestinal motility. This could reduce antimicrobial efficacy, and the intranasal form may behave similarly.
What this interaction means in plain words
Atovaquone and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Altered gastrointestinal motility may reduce atovaquone absorption.
What to do
Monitor for reduced atovaquone response and consider an alternative antiemetic if treatment failure is a concern.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atovaquone
- Atovaquone + Rifampin Major
- Atovaquone + Efavirenz Moderate
- Atovaquone + Metoclopramide Moderate
- Atovaquone + Rifabutin Moderate
- Atovaquone + Warfarin Moderate
- Atovaquone + Indinavir Minor
Frequently asked questions
Can I take Atovaquone with Metoclopramide intranasal?
MediHelp rates the interaction as minor. Atovaquone and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral metoclopramide has been reported to lower atovaquone plasma concentrations, possibly through its effect on gastrointestinal motility. This could reduce antimicrobial efficacy, and the intranasal form may behave similarly.
How serious is the interaction between Atovaquone and Metoclopramide intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced atovaquone response and consider an alternative antiemetic if treatment failure is a concern.
What other medicines interact with Atovaquone?
MediHelp also lists interactions of Atovaquone with, for example, Rifampin, Efavirenz, Metoclopramide. The full list is on the Atovaquone page.
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