Drug interactions
Atovaquone + Metoclopramide
Severity: Moderate
Atovaquone and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may reduce the absorption of atovaquone, a drug with limited and variable oral bioavailability. Lower atovaquone levels could reduce efficacy in malaria or Pneumocystis infection.
What this interaction means in plain words
Atovaquone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atovaquone belongs to Anti Parasitic; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Faster GI transit lowers dissolution and absorption of atovaquone; the effect is not fully characterized.
What to do
Take atovaquone with a fatty meal and watch for treatment failure. Consider another antiemetic if vomiting or poor response occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Atovaquone
- Atovaquone + Rifampin Major
- Atovaquone + Efavirenz Moderate
- Atovaquone + Rifabutin Moderate
- Atovaquone + Warfarin Moderate
- Atovaquone + Indinavir Minor
- Atovaquone + Metoclopramide intranasal Minor
Frequently asked questions
Can I take Atovaquone with Metoclopramide?
MediHelp rates the interaction as moderate. Atovaquone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide may reduce the absorption of atovaquone, a drug with limited and variable oral bioavailability. Lower atovaquone levels could reduce efficacy in malaria or Pneumocystis infection.
How serious is the interaction between Atovaquone and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take atovaquone with a fatty meal and watch for treatment failure. Consider another antiemetic if vomiting or poor response occurs.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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