Drug interactions
Atracurium + Carbachol
Severity: Minor
Atracurium and Carbachol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a cholinergic agonist that acts at muscarinic and nicotinic receptors, which could in theory oppose the nicotinic blockade produced by atracurium. Clinical data are scarce and the effect is unpredictable, particularly with ophthalmic use where systemic exposure is small.
What this interaction means in plain words
Atracurium and Carbachol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atracurium belongs to Musculoskeletal; Carbachol belongs to Miscellaneous.
Why it happens
Theoretical pharmacodynamic antagonism between a cholinergic agonist and a competitive nondepolarizing neuromuscular blocker at the neuromuscular junction.
What to do
No routine action for topical ocular carbachol; with systemic exposure, monitor neuromuscular blockade with train-of-four and adjust atracurium dosing as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atracurium
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Atracurium with Carbachol?
MediHelp rates the interaction as minor. Atracurium and Carbachol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbachol is a cholinergic agonist that acts at muscarinic and nicotinic receptors, which could in theory oppose the nicotinic blockade produced by atracurium. Clinical data are scarce and the effect is unpredictable, particularly with ophthalmic use where systemic exposure is small.
How serious is the interaction between Atracurium and Carbachol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action for topical ocular carbachol; with systemic exposure, monitor neuromuscular blockade with train-of-four and adjust atracurium dosing as needed.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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