Drug interactions
Atracurium + Doxepin
Severity: Minor
Atracurium and Doxepin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin has anticholinergic properties, but its effect on nicotinic neuromuscular blockade is minor. Clinically significant potentiation of atracurium is not well documented.
What this interaction means in plain words
Atracurium and Doxepin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atracurium belongs to Musculoskeletal; Doxepin belongs to Dermatology.
Why it happens
Theoretical additive anticholinergic effect; tricyclics have weak neuromuscular effects at high doses.
What to do
No specific action beyond routine train-of-four monitoring during anesthesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atracurium
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Atracurium with Doxepin?
MediHelp rates the interaction as minor. Atracurium and Doxepin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxepin has anticholinergic properties, but its effect on nicotinic neuromuscular blockade is minor. Clinically significant potentiation of atracurium is not well documented.
How serious is the interaction between Atracurium and Doxepin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action beyond routine train-of-four monitoring during anesthesia.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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