Drug interactions
Atracurium + Neomycin
Severity: Moderate
Atracurium and Neomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can intensify and prolong neuromuscular blockade from non-depolarizing agents, risking prolonged paralysis and respiratory depression. Oral neomycin is poorly absorbed but absorption can occur with bowel disease or high doses.
What this interaction means in plain words
Atracurium and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Neomycin belongs to Anti Bacterial.
Why it happens
Aminoglycoside reduction of presynaptic acetylcholine release and postsynaptic sensitivity adds to non-depolarizing blockade.
What to do
Monitor neuromuscular function with train-of-four and be ready to provide ventilatory support during and after surgery. Reduce the muscle relaxant dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atracurium and Neomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Atracurium
Frequently asked questions
Can I take Atracurium with Neomycin?
MediHelp rates the interaction as moderate. Atracurium and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can intensify and prolong neuromuscular blockade from non-depolarizing agents, risking prolonged paralysis and respiratory depression. Oral neomycin is poorly absorbed but absorption can occur with bowel disease or high doses.
How serious is the interaction between Atracurium and Neomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and be ready to provide ventilatory support during and after surgery. Reduce the muscle relaxant dose as needed.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
