Drug interactions
Atracurium + Oliceridine
Severity: Moderate
Atracurium and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids add to respiratory depression and sedation in the perioperative period, and may increase the risk of residual weakness or hypoventilation with neuromuscular blockers. In anesthesia, ventilation is controlled, so the risk is mainly during recovery.
What this interaction means in plain words
Atracurium and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive respiratory and CNS depression with possible enhancement of neuromuscular blockade.
What to do
Monitor neuromuscular blockade and ventilation until full recovery. Titrate oliceridine to effect and observe closely for post-operative respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atracurium
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Atracurium with Oliceridine?
MediHelp rates the interaction as moderate. Atracurium and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids add to respiratory depression and sedation in the perioperative period, and may increase the risk of residual weakness or hypoventilation with neuromuscular blockers. In anesthesia, ventilation is controlled, so the risk is mainly during recovery.
How serious is the interaction between Atracurium and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade and ventilation until full recovery. Titrate oliceridine to effect and observe closely for post-operative respiratory depression.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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