Drug interactions
Isocarboxazid + Oliceridine
Severity: Contraindicated
Isocarboxazid and Oliceridine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with MAOIs carry risk of serotonin syndrome and potentiated opioid effects including respiratory depression. Oliceridine labeling advises against use within 14 days of MAOIs.
What this interaction means in plain words
Isocarboxazid and Oliceridine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
MAO inhibition may cause serotonergic excess and potentiate opioid CNS and respiratory depression.
What to do
Avoid oliceridine during and within 14 days after stopping isocarboxazid; use a non-opioid or alternative analgesic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Oliceridine
Frequently asked questions
Can I take Isocarboxazid with Oliceridine?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Oliceridine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids combined with MAOIs carry risk of serotonin syndrome and potentiated opioid effects including respiratory depression. Oliceridine labeling advises against use within 14 days of MAOIs.
How serious is the interaction between Isocarboxazid and Oliceridine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oliceridine during and within 14 days after stopping isocarboxazid; use a non-opioid or alternative analgesic.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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