Drug interactions
Amobarbital + Oliceridine
Severity: Major
Amobarbital and Oliceridine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a barbiturate can cause profound sedation, respiratory depression, coma and death. Amobarbital also induces CYP3A4 and may lower oliceridine exposure, reducing analgesia, with risk of toxicity if the inducer is stopped.
What this interaction means in plain words
Amobarbital and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression plus CYP3A4 induction that increases oliceridine metabolism.
What to do
Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration with continuous respiratory and sedation monitoring. Titrate oliceridine to effect and reduce the dose with monitoring if amobarbital is discontinued.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Aripiprazole + Oliceridine Major
Frequently asked questions
Can I take Amobarbital with Oliceridine?
MediHelp rates the interaction as major. Amobarbital and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a barbiturate can cause profound sedation, respiratory depression, coma and death. Amobarbital also induces CYP3A4 and may lower oliceridine exposure, reducing analgesia, with risk of toxicity if the inducer is stopped.
How serious is the interaction between Amobarbital and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration with continuous respiratory and sedation monitoring. Titrate oliceridine to effect and reduce the dose with monitoring if amobarbital is discontinued.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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