Drug interactions
Atracurium + Prednisone
Severity: Moderate
Atracurium and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given with nondepolarizing neuromuscular blockers, especially in critically ill patients on prolonged infusions, are associated with acute myopathy. Corticosteroids can also alter the duration of neuromuscular blockade.
What this interaction means in plain words
Atracurium and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Prednisone belongs to Endocrine.
Why it happens
Additive muscle injury and altered neuromuscular transmission; mechanism not fully established.
What to do
Limit the duration of neuromuscular blockade, use a nerve stimulator to titrate dosing, and monitor for prolonged weakness and creatine kinase elevation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Atracurium
Frequently asked questions
Can I take Atracurium with Prednisone?
MediHelp rates the interaction as moderate. Atracurium and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with nondepolarizing neuromuscular blockers, especially in critically ill patients on prolonged infusions, are associated with acute myopathy. Corticosteroids can also alter the duration of neuromuscular blockade.
How serious is the interaction between Atracurium and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration of neuromuscular blockade, use a nerve stimulator to titrate dosing, and monitor for prolonged weakness and creatine kinase elevation.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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