Drug interactions
Atracurium + Quinidine
Severity: Moderate
Atracurium and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine has neuromuscular blocking activity and can potentiate nondepolarizing blockers. This may prolong blockade or cause recurrent weakness after reversal.
What this interaction means in plain words
Atracurium and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine adds postsynaptic neuromuscular blocking and membrane-stabilizing effects to nondepolarizing blockade.
What to do
Monitor train-of-four and reduce atracurium doses as needed. Continue monitoring respiratory function after reversal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atracurium
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Atracurium with Quinidine?
MediHelp rates the interaction as moderate. Atracurium and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine has neuromuscular blocking activity and can potentiate nondepolarizing blockers. This may prolong blockade or cause recurrent weakness after reversal.
How serious is the interaction between Atracurium and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor train-of-four and reduce atracurium doses as needed. Continue monitoring respiratory function after reversal.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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