Drug interactions
Atracurium + Verapamil
Severity: Moderate
Atracurium and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may potentiate and prolong neuromuscular blockade from nondepolarizing agents such as atracurium. Recovery may be slower than expected.
What this interaction means in plain words
Atracurium and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Verapamil belongs to Cardiovascular.
Why it happens
Calcium channel blockade reduces presynaptic acetylcholine release, adding to postsynaptic nondepolarizing blockade.
What to do
Monitor train-of-four and reduce atracurium dosing as needed. Watch for delayed recovery or recurrent weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atracurium
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Atracurium with Verapamil?
MediHelp rates the interaction as moderate. Atracurium and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may potentiate and prolong neuromuscular blockade from nondepolarizing agents such as atracurium. Recovery may be slower than expected.
How serious is the interaction between Atracurium and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor train-of-four and reduce atracurium dosing as needed. Watch for delayed recovery or recurrent weakness.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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