Drug interactions
Atropine + Belladonna and opium
Severity: Moderate
Atropine and Belladonna and opium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna and opium combines antimuscarinic alkaloids with an opioid, so adding atropine increases anticholinergic effects. Constipation, urinary retention, paralytic ileus, tachycardia and confusion are possible, and the opioid adds sedation.
What this interaction means in plain words
Atropine and Belladonna and opium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects, with opioid-induced reduction in gut motility and urinary retention.
What to do
Avoid concurrent use where possible. If combined, monitor bowel and bladder function and mental status, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atropine and Belladonna and opium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Belladonna and opium?
MediHelp rates the interaction as moderate. Atropine and Belladonna and opium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna and opium combines antimuscarinic alkaloids with an opioid, so adding atropine increases anticholinergic effects. Constipation, urinary retention, paralytic ileus, tachycardia and confusion are possible, and the opioid adds sedation.
How serious is the interaction between Atropine and Belladonna and opium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If combined, monitor bowel and bladder function and mental status, and use the lowest effective doses.
What other medicines interact with Atropine?
MediHelp also lists interactions of Atropine with, for example, Eluxadoline, Henbane, Pramlintide. The full list is on the Atropine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
