Drug interactions
Atropine + Eluxadoline
Severity: Major
Atropine and Eluxadoline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline slows gut transit and can cause constipation and pancreatitis-related events, and atropine adds antimuscarinic suppression of gut motility. Together they raise the risk of severe constipation, ileus and related complications.
What this interaction means in plain words
Atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atropine belongs to Miscellaneous; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Additive inhibition of gastrointestinal motility through opioid receptor agonism (eluxadoline) and muscarinic blockade (atropine).
What to do
Avoid routine coadministration. If an anticholinergic is needed, monitor for constipation and abdominal distension and stop eluxadoline if severe constipation develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Atropine
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
- Amitriptyline + Atropine Moderate
Other interactions of Eluxadoline
Frequently asked questions
Can I take Atropine with Eluxadoline?
MediHelp rates the interaction as major. Atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline slows gut transit and can cause constipation and pancreatitis-related events, and atropine adds antimuscarinic suppression of gut motility. Together they raise the risk of severe constipation, ileus and related complications.
How serious is the interaction between Atropine and Eluxadoline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine coadministration. If an anticholinergic is needed, monitor for constipation and abdominal distension and stop eluxadoline if severe constipation develops.
What other medicines interact with Atropine?
MediHelp also lists interactions of Atropine with, for example, Henbane, Pramlintide, Abobotulinumtoxina. The full list is on the Atropine page.
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