Drug interactions
Atropine + Glycopyrronium tosylate
Severity: Moderate
Atropine and Glycopyrronium tosylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical glycopyrronium has some systemic absorption, and atropine is a systemically active antimuscarinic. Together they may produce additive anticholinergic effects such as dry mouth, blurred vision, urinary retention, constipation and tachycardia.
What this interaction means in plain words
Atropine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic effects, especially in older adults and in patients with glaucoma or urinary retention. Reduce use or stop glycopyrronium if they emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Glycopyrronium tosylate?
MediHelp rates the interaction as moderate. Atropine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topical glycopyrronium has some systemic absorption, and atropine is a systemically active antimuscarinic. Together they may produce additive anticholinergic effects such as dry mouth, blurred vision, urinary retention, constipation and tachycardia.
How serious is the interaction between Atropine and Glycopyrronium tosylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, especially in older adults and in patients with glaucoma or urinary retention. Reduce use or stop glycopyrronium if they emerge.
What other medicines interact with Atropine?
MediHelp also lists interactions of Atropine with, for example, Eluxadoline, Henbane, Pramlintide. The full list is on the Atropine page.
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