Drug interactions
Atropine + Lofepramine
Severity: Moderate
Atropine and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine, a tricyclic antidepressant, has anticholinergic properties that add to those of atropine. This can cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, and may precipitate angle-closure glaucoma.
What this interaction means in plain words
Atropine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic adverse effects, especially in elderly patients and those with glaucoma, prostatic hypertrophy or ileus risk. Reduce doses or choose a less anticholinergic agent if effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Lofepramine?
MediHelp rates the interaction as moderate. Atropine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine, a tricyclic antidepressant, has anticholinergic properties that add to those of atropine. This can cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, and may precipitate angle-closure glaucoma.
How serious is the interaction between Atropine and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially in elderly patients and those with glaucoma, prostatic hypertrophy or ileus risk. Reduce doses or choose a less anticholinergic agent if effects occur.
What other medicines interact with Atropine?
MediHelp also lists interactions of Atropine with, for example, Eluxadoline, Henbane, Pramlintide. The full list is on the Atropine page.
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