Drug interactions
Atropine + Olanzapine / samidorphan
Severity: Moderate
Atropine and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is anticholinergic, so adding atropine increases antimuscarinic effects including constipation, urinary retention, dry mouth and tachycardia. Severe gastrointestinal hypomotility, including ileus, is the main concern.
What this interaction means in plain words
Atropine and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects causing reduced gastrointestinal and urinary tract motility.
What to do
Monitor bowel function and urinary symptoms and treat constipation early. Avoid additional anticholinergics where possible, especially in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Atropine and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine is anticholinergic, so adding atropine increases antimuscarinic effects including constipation, urinary retention, dry mouth and tachycardia. Severe gastrointestinal hypomotility, including ileus, is the main concern.
How serious is the interaction between Atropine and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary symptoms and treat constipation early. Avoid additional anticholinergics where possible, especially in elderly patients.
What other medicines interact with Atropine?
MediHelp also lists interactions of Atropine with, for example, Eluxadoline, Henbane, Pramlintide. The full list is on the Atropine page.
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