Drug interactions
Atropine + Olanzapine
Severity: Moderate
Atropine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has anticholinergic activity, so adding atropine increases the risk of dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Elderly patients are particularly susceptible, and severe constipation or ileus may occur.
What this interaction means in plain words
Atropine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Olanzapine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic toxicity, including bowel function, urinary retention and delirium, and use the lowest effective atropine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Olanzapine?
MediHelp rates the interaction as moderate. Atropine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has anticholinergic activity, so adding atropine increases the risk of dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Elderly patients are particularly susceptible, and severe constipation or ileus may occur.
How serious is the interaction between Atropine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, including bowel function, urinary retention and delirium, and use the lowest effective atropine dose.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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