Drug interactions
Atropine + Umeclidinium bromide
Severity: Moderate
Atropine and Umeclidinium bromide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Umeclidinium is an inhaled long-acting antimuscarinic with low but real systemic exposure, so adding atropine may increase anticholinergic effects such as dry mouth, urinary retention, constipation and tachycardia. Ocular effects including angle-closure glaucoma may also be heightened.
What this interaction means in plain words
Atropine and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Monitor for systemic anticholinergic effects, urinary retention and eye pain or visual changes. Avoid other anticholinergics where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Umeclidinium bromide?
MediHelp rates the interaction as moderate. Atropine and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Umeclidinium is an inhaled long-acting antimuscarinic with low but real systemic exposure, so adding atropine may increase anticholinergic effects such as dry mouth, urinary retention, constipation and tachycardia. Ocular effects including angle-closure glaucoma may also be heightened.
How serious is the interaction between Atropine and Umeclidinium bromide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic anticholinergic effects, urinary retention and eye pain or visual changes. Avoid other anticholinergics where possible.
What other medicines interact with Atropine?
MediHelp also lists interactions of Atropine with, for example, Eluxadoline, Henbane, Pramlintide. The full list is on the Atropine page.
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