Drug interactions
Atropine iv / + Desipramine
Severity: Moderate
Atropine iv / and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine has anticholinergic properties that add to the effects of atropine. This can increase tachycardia, dry mouth, urinary retention, constipation, confusion and heat intolerance, especially in older patients.
What this interaction means in plain words
Atropine iv / and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor heart rate, mental status and urinary and bowel function. Use the lowest effective atropine dose, particularly in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Atropine iv / with Desipramine?
MediHelp rates the interaction as moderate. Atropine iv / and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine has anticholinergic properties that add to the effects of atropine. This can increase tachycardia, dry mouth, urinary retention, constipation, confusion and heat intolerance, especially in older patients.
How serious is the interaction between Atropine iv / and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, mental status and urinary and bowel function. Use the lowest effective atropine dose, particularly in elderly patients.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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